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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MSH6
All Species:
4.24
Human Site:
S315
Identified Species:
6.67
UniProt:
P52701
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P52701
NP_000170.1
1360
152786
S315
G
S
L
K
R
K
S
S
R
K
E
T
P
S
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001113749
1360
152750
S315
G
S
L
K
R
K
S
S
R
K
E
M
P
S
A
Dog
Lupus familis
XP_531814
1283
145094
E298
T
L
E
W
L
K
E
E
K
R
R
D
L
H
R
Cat
Felis silvestris
Mouse
Mus musculus
P54276
1358
151058
L315
G
G
L
R
R
K
S
L
K
K
E
T
G
S
A
Rat
Rattus norvegicus
XP_002726765
1361
151628
L318
G
G
L
K
R
K
S
L
K
K
E
T
G
S
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_419359
1466
164165
P419
K
R
G
N
V
S
K
P
S
K
R
S
S
L
E
Frog
Xenopus laevis
NP_001089247
1340
149481
L298
A
S
G
P
K
K
R
L
Q
N
E
Q
S
E
T
Zebra Danio
Brachydanio rerio
NP_878280
1369
153213
K317
K
P
T
K
S
K
S
K
P
E
T
P
K
R
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VUM0
1190
133117
W220
N
L
D
E
P
V
V
W
P
H
Q
K
L
E
F
Honey Bee
Apis mellifera
XP_392346
1120
127429
G150
F
G
K
K
P
Q
K
G
A
K
K
N
F
K
E
Nematode Worm
Caenorhab. elegans
NP_491163
1186
133609
F216
F
D
H
E
S
F
D
F
L
K
P
D
K
I
R
Sea Urchin
Strong. purpuratus
XP_797647
1335
149141
P297
T
N
K
S
A
K
K
P
R
S
V
L
T
P
F
Poplar Tree
Populus trichocarpa
XP_002320307
1288
142120
P305
D
P
R
T
L
Y
L
P
A
E
F
A
K
S
L
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
O04716
1324
146779
I298
S
K
T
D
T
G
T
I
L
K
G
F
K
A
S
Baker's Yeast
Sacchar. cerevisiae
Q03834
1242
140062
Q272
K
S
S
K
F
N
K
Q
N
E
E
R
Y
Q
W
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.3
88.1
N.A.
85.8
86.4
N.A.
N.A.
64.2
66.5
60
N.A.
39
41.2
34.4
48.6
Protein Similarity:
100
N.A.
98.6
91.3
N.A.
92.1
92.8
N.A.
N.A.
75.4
79.9
74.9
N.A.
57.6
58
52.7
66.6
P-Site Identity:
100
N.A.
93.3
6.6
N.A.
66.6
73.3
N.A.
N.A.
6.6
20
26.6
N.A.
0
13.3
6.6
13.3
P-Site Similarity:
100
N.A.
93.3
20
N.A.
80
80
N.A.
N.A.
13.3
33.3
33.3
N.A.
13.3
26.6
13.3
20
Percent
Protein Identity:
36.1
N.A.
N.A.
33.2
29
N.A.
Protein Similarity:
52
N.A.
N.A.
51.4
49.1
N.A.
P-Site Identity:
6.6
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
13.3
N.A.
N.A.
26.6
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
7
0
0
0
7
0
0
0
14
0
0
7
0
7
34
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
7
7
7
0
0
7
0
0
0
0
14
0
0
0
% D
% Glu:
0
0
7
14
0
0
7
7
0
20
40
0
0
14
14
% E
% Phe:
14
0
0
0
7
7
0
7
0
0
7
7
7
0
14
% F
% Gly:
27
20
14
0
0
7
0
7
0
0
7
0
14
0
0
% G
% His:
0
0
7
0
0
0
0
0
0
7
0
0
0
7
0
% H
% Ile:
0
0
0
0
0
0
0
7
0
0
0
0
0
7
0
% I
% Lys:
20
7
14
40
7
54
27
7
20
54
7
7
27
7
0
% K
% Leu:
0
14
27
0
14
0
7
20
14
0
0
7
14
7
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
7
0
0
0
% M
% Asn:
7
7
0
7
0
7
0
0
7
7
0
7
0
0
0
% N
% Pro:
0
14
0
7
14
0
0
20
14
0
7
7
14
7
0
% P
% Gln:
0
0
0
0
0
7
0
7
7
0
7
7
0
7
0
% Q
% Arg:
0
7
7
7
27
0
7
0
20
7
14
7
0
7
14
% R
% Ser:
7
27
7
7
14
7
34
14
7
7
0
7
14
34
7
% S
% Thr:
14
0
14
7
7
0
7
0
0
0
7
20
7
0
7
% T
% Val:
0
0
0
0
7
7
7
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
7
0
0
0
7
0
0
0
0
0
0
7
% W
% Tyr:
0
0
0
0
0
7
0
0
0
0
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _